Assessment of a power law relationship between P-band SAR backscatter and aboveground biomass and its implications for BIOMASS mission performance

This paper presents an analysis of a logarithmic relationship between P-band cross-polarized backscatter from synthetic aperture radar (SAR) and aboveground biomass (AGB) across different forest types based on multiple airborne datasets. It is found that the logarithmic function provides a statistically significant fit to the observed relationship between HV backscatter and AGB. While the coefficient of determination varies between datasets, the slopes, and intercepts of many of the models are not significantly different, especially when similar AGB ranges are assessed. Pooled boreal and pooled tropical data have slopes that are not significantly different, but they have different intercepts. Using the power law formulation of the logarithmic relation allows estimation of both the equivalent number of looks (ENL) needed to retrieve AGB with a given uncertainty and the sensitivity of the AGB inversion. The campaign data indicates that boreal forests require a larger ENL than tropical forests to achieve a specified relative accuracy. The ENL can be increased by multichannel filtering, but ascending and descending images will need to be combined to meet the performance requirements of the BIOMASS mission. The analysis also indicates that the relative change in AGB associated with a given backscatter change depends only on the magnitude of the change and the exponent of the power law, and further implies that to achieve a relative AGB accuracy of 20% or better, residual errors from radiometric distortions produced by the system and environmental effects must not exceed 0.43 dB in tropical and 0.39 dB in boreal forests

Drug Delivery Micropump with Built-In Monitoring

AbstractWe report on the fabrication of the first MEMS micropump including an integrated pressure sensor. The signal of this sensor allows direct insight into the pump's operating dynamics and enables real-time self-monitoring. We demonstrate the changes in the sensor signal under different pumping conditions, including the presence of air in the pumping chamber and a downstream occlusions. Deviations from normal operating conditions create clear and characteristic deviations from the normal signal. These deviations will be exploited to detect extraordinary or faulty pumping conditions during use

Relationship of Canopy Cover with TanDEM-X Features in a Tropical Peat Swamp Forest

Monitoring of tropical forests and peat swamp forests becomes increasingly important in order to reduce carbon emissions from deforestation and forest degradation. SAR systems are suitable for that purpose due to their weather independence and sensitivity for changes in time series. The TanDEM-X mission delivers global datasets of a single-pass SAR interferometer, which provides more information in comparison to normal X-band SAR acquisitions. In particular the interferometric coherence can be regarded as useful information because it is dependent on tree height and canopy cover representing stand structure, which are important parameters for monitoring of forests

Do Emergent Constraints on Carbon Cycle Feedbacks hold in CMIP6?

Emergent constraints on carbon cycle feedbacks in response to warming and increasing atmospheric CO2 concentration have previously been identified in Earth system models (ESMs) participating in the Coupled Model Intercomparison Project (CMIP) Phase 5. Here we examine whether two of these emergent constraints also hold for CMIP6. The spread of the sensitivity of tropical land carbon uptake to tropical warming in an idealized simulation with a 1% per year increase of atmospheric CO2 shows only a slight decrease in CMIP6 (-52 ± 35 GtC/K) compared to CMIP5 (-49 ± 40 GtC/K). For both model generations, the observed interannual variability in the growth rate of atmospheric CO2 yields a consistent emergent constraint on the sensitivity of tropical land carbon uptake with a constrained range of -37 ± 14 GtC/K for the combined ensemble (i.e., a reduction of ~30% in the best estimate and 60% in the uncertainty range relative to the multi-model mean of the combined ensemble). A further emergent constraint is based on a relationship between CO2 fertilization and the historical increase in the CO2 seasonal cycle amplitude in high latitudes. However, this emergent constraint is not evident in CMIP6. This is in part because the historical increase in the amplitude of the CO2 seasonal cycle is more accurately simulated in CMIP6, such that the models are all now close to the observational constraint

Preclinical testing of an oncolytic parvovirus in Ewing sarcoma : protoparvovirus H-1 induces apoptosis and lytic infection in vitro but fails to improve survival in vivo

About 70% of all Ewing sarcoma (EWS) patients are diagnosed under the age of 20 years. Over the last decades little progress has been made towards finding effective treatment approaches for primarily metastasized or refractory Ewing sarcoma in young patients. Here, in the context of the search for novel therapeutic options, the potential of oncolytic protoparvovirus H-1 (H-1PV) to treat Ewing sarcoma was evaluated, its safety having been proven previously tested in adult cancer patients and its oncolytic efficacy demonstrated on osteosarcoma cell cultures. The effects of viral infection were tested in vitro on four human Ewing sarcoma cell lines. Notably evaluated were effects of the virus on the cell cycle and its replication efficiency. Within 24 h after infection, the synthesis of viral proteins was induced. Efficient H-1PV replication was confirmed in all four Ewing sarcoma cell lines. The cytotoxicity of the virus was determined on the basis of cytopathic effects, cell viability, and cell lysis. These in vitro experiments revealed efficient killing of Ewing sarcoma cells by H-1PV at a multiplicity of infection between 0.1 and 5 plaque forming units (PFU)/cell. In two of the four tested cell lines, significant induction of apoptosis by H-1PV was observed. H-1PV thus meets all the in vitro criteria for a virus to be oncolytic towards Ewing sarcoma. In the first xenograft experiments, however, although an antiproliferative effect of intratumoral H-1PV injection was observed, no significant improvement of animal survival was noted. Future projects aiming to validate parvovirotherapy for the treatment of pediatric Ewing sarcoma should focus on combinatorial treatments and will require the use of patient-derived xenografts and immunocompetent syngeneic animal models

Examining the neural correlates of emergent equivalence relations in fragile X syndrome

The neural mechanisms underlying the formation of stimulus equivalence relations are poorly understood, particularly in individuals with specific learning impairments. As part of a larger study, we used functional magnetic resonance imaging (fMRI) while participants with fragile X syndrome (FXS), and age- and IQ-matched controls with intellectual disability, were required to form new equivalence relations in the scanner. Following intensive training on matching fractions to pie charts (A=B relations) and pie charts to decimals (B=C relations) outside the scanner over a 2- day period, participants were tested on the trained (A=B, B=C) relations, as well as emergent symmetry (i.e., B=A and C=B) and transitivity/equivalence (i.e., A=C and C=A) relations inside the scanner. Eight participants with FXS (6 female, 2 male) and 10 controls, aged 10–23 years, were able to obtain at least 66.7% correct on the trained relations in the scanner and were included in the fMRI analyses. Across both groups, results showed that the emergence of symmetry relations was correlated with increased brain activation in the left inferior parietal lobule, left postcentral gyrus, and left insula, broadly supporting previous investigations of stimulus equivalence research in neurotypical populations. On the test of emergent transitivity/equivalence relations, activation was significantly greater in individuals with FXS compared with controls in the right middle temporal gyrus, left superior frontal gyrus and left precuneus. These data indicate that neural execution was significantly different in individuals with FXS than in age- and IQ-matched controls during stimulus equivalence formation. Further research concerning how gene–brain–behavior interactions may influence the emergence of stimulus equivalence in individuals with intellectual disabilities is needed